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 В 1981 году в соответствии с решением Коллегии Государственного Комитета СССР, Постановлением Совета Министров РСФСР и Приказом Министерства здравоохранения СССР в г. Благовещенске был организован Научно-исследовательский институт физиологии и патологии дыхания Сибирского отделения Академии медицинских наук СССР.   

    В 1998 году в соответствии с Приказом Академии медицинских наук произошла реорганизация Дальневосточного научного центра физиологии и патологии дыхания СО РАМН, г. Благовещенск, путем слияния НИИ физиологии и патологии дыхания, НИИ медицинской климатологии и восстановительного лечения (НИИ МКВЛ, Владивостокский филиал), НИИ охраны материнства и детства (Хабаровский филиал).

Полное наименование: Федеральное государственное бюджетное научное учреждение «Дальневосточный научный центр физиологии и патологии дыхания»

Сокращенное наименование: ДНЦ ФПД

Адреса:

Амурская обл., г. Благовещенск, ул. Калинина, д. 22 - администрация, научно-методический отдел, научные лаборатории, клинико-диагностическое отделение клиники для взрослых, лечебные подразделения клиники для взрослых  тел.: (4162) 77-28-08, (4162) 77-17-28, (4162) 77-17-29, (4162) 77-17-32, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.

Амурская обл., г. Благовещенск, ул. Горького, д. 95 «а» - лаборатория механизмов этиопатогенеза и восстановительных процессов дыхательной системы при неспецифических заболеваниях легких   тел.: (4162) 77-28-15

Владивостокский филиал ДНЦ ФПД - НИИ МКВЛ: 690105, Владивосток, Русская 73-г,  тел/факс: 8(423) 2788-201, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра., сайт: http://niivl.ru

Хабаровский филиал ДНЦ ФПД - НИИ ОМиД: 680022, г. Хабаровск, ул. Воронежская 49, корп. 1, тел/факс: (4212) 98-03-35, 98-01-37, e-mail:Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.. Сайт: http://iomid.ru

 Схема проезда

Схема2

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ORIGINAL RESEARCH
T.A.Gvozdenko, I.N.Simonova, M.V.Antonyuk, L.V.Veremchuk, T.I.Vitkina. Pathogenetic markers of ecologically related respiratory diseases

The aim of the research is to examine the relationship between the integral parameters of respiratory function, the values of LPO-AOD system and NO level at bronchopulmonary pathology in individuals living in different ecological areas of the city of Vladivostok. 206 patients living in different ecological conditions (healthy individuals, patients with respiratory disorders) were examined. Lung function and the state of LPO-AOD system were studied; the concentration of NO metabolites was assessed in blood serum. The nature and strength of the impact of environmental factors on respiratory function, the state of LPO-AOD, NO level were studied by the method based on correlation analysis. There was calculated power index (D) which was differentiated into power within the system (Ds) which in its turn reflects the in-system interrelationship tension (LPO-AOD, respiratory) and power between systems (Dm) characterizing the activity of interconnections and response to an external stimulus. Intra-system dependences typical for the unfavorable zone were viewed in relation to the favorable zone. It was found out that in ecologically unfavorable regions in individuals with different bronchopulmonary pathologies the value of Ds increases. This indicates that the pathogenic influence of environmental factors increases. In healthy people living in ecologically unfavourable area physiological adaptive-compensatory reaction of the body was revealed, which was proved by high power interconnections (Dm). In the patients with chronic bronchitis there was maintained an adequate level of functioning of the body systems studied. In patients with COPD living in an unfavourable zone there were found strong links between the indicators of the system of LPO-AOD and of NO, and in patients with bronchial asthma - supplementary relationship between lung function and NO. At the same time pathologic changes in the system of LPO-AOD and NO depend on the general pollution, metal and gas components contained in the air. Thus, the people with respiratory diseases being in environmentally unfavorable conditions have the most negative influence. The analysis of the activity of relationships proved that violations of interaction of LPO-AOD systems and NO in ecologically unfavorable regions may contribute to the occurrence and progression of bronchopulmonary diseases.

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A.P.Bondarenko, V.A.Shmylenko, O.E.Trotsenko, T.A.Zaitseva, T.N.Karavyanskaya, L.V.Butakova, T.V.Korita. Annual dynamics of pneumococcal carriage and communityacquired pneumonia incidence in Khabarovsk city in 2015

The research objective was to study prevalence of pneumococcal nasopharyngeal carriage among different age-group populations as well as evaluate annual dynamics of nasopharyngeal carriage levels against incidence rates of community-acquired pneumonia in Khabarovsk city in 2015. The bacteriological research was conducted among 2429 people (1100 adults and 1329 children) suffering from respiratory diseases. The level of pneumococcal carriage of the whole group was equal to 12.3±0.67%. The pneumococcal carriage was registered in all age-groups; its highest levels were diagnosed in children from 1 to 3 years old and in children from 3 to 6 years old (27.0±2.16 and 23.1±1.97%, respectively). The incidence rates of community-acquired pneumonia equaled to 290.2 per 100000 of general population and 687.1 per 100000 of children population. The comparative analysis of annual dynamics of pneumococcal carriage and community-acquired pneumonia incidence rates among general population of Khabarovsk city and separately for children from 0 to 14 years old has shown a correlation between these epidemiologic manifestations. Typically, pneumococcal carriage and incidence rates are the lowest in August; they elevate in September due to influence of common factors that are associated with “mixing” of people. The peculiarity of annual dynamic of community-acquired pneumonia incidence rates is a double-wave course with maximum in April and September. The revealed trends show the correlation between epidemic process of community-acquired pneumonia and undetected epidemic process of pneumococcal infections manifested as pneumococcal carriage.

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L.V.Butakova, R.A.Gladkikh, O.E.Trotsenko, V.P.Molochniy, E.Yu.Sapega, I.E.Shchegoleva. Structure of acute respiratory viral infections among hospitalized children of Khabarovsk in epidemic season of 2015-2016

The research presents results of the analysis by polymerase chain reaction of clinical material obtained from 170 children hospitalized into an infectious department of the Khabarovsk children’s territorial clinical hospital named after A.K.Piotrovich with a diagnosis of acute viral infection in epidemic season of 2015-2016. The most numerous group consisted of children under 1st year of age – 74 children (43.5%). The overall number of detected respiratory viruses was equal to 179. Most prevalent viruses were human rhinoviruses (25.1%), human adenoviruses (19.6%), and human parainfluenza viruses (16.8%). Among influenza viruses (11.7%) type A(H1N1) pdm09 was predominant. In 92 children (54.1%) the disease was caused by a mono-infection, in 40 cases (23.5%) there was identified mixed-infection. Infections of lower respiratory tract were identified in 100 patients (58.8%), stenosing laryngotracheitis was diagnosed most frequently (20.6%).

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N.V.Korzhova. Pharmacoeconomic analysis of the effectiveness of antibiotic therapy of nosocomial pneumonia

There was performed a prospective pharmacoeconomic study of effectiveness of different variants of antibacterial therapy in 118 patients diagnosed with nosocomial pneumonia who were treated in specialized departments of General hospital to identify the most effective treatment regimens from the point of view of pharmacoeconomics. Taking into account the characteristics of the local microbiological pattern and the spectrum of sensitivity to antibiotics of the most commonly encountered microorganisms in this hospital there were selected the drugs that have high activity against these pathogens. The patients were divided into groups: the first group (n=57) included the patients with early nosocomial pneumonia including 37 patients receiving combination therapy with Levofloxacin and Ceftazidime, 20 patients with Amoxiclav monotherapy; the second group (n=61) consisted of patients with later nosocomial pneumonia; 34 patients had combined treatment with Amikacin and Cefoperazone/Sulbactam, 27 patients had Imipenem monotherapy. The evaluation and analysis of clinical effectiveness with the method "cost-effectiveness" were done. It was found out that in all compared groups there is a high effectiveness of antibacterial drugs starting from 61%. The highest integral factor of clinical efficacy was in the group of Imipenem (86.1%), then in the group of Levofloxacin and Ceftazidime (71.5%), in the group of Amikacin and Cefoperazon/Sulbactam (70%), in the group of Amoxiclav (61%). Noteworthy is that only in the group of Imipenem there was no need for additional antibacterial therapy and there was short term treatment. While analyzing the cost-effectiveness correlation, it was found out that the least cost per unit of effectiveness was the cost of treatment with the combination of Levofloxacin and Ceftazidime for patients with early nosocomial pneumonia and the cost of therapy with Amikacin and Cefoperazon/Sulbactam in patients with late nosocomial pneumonia. Despite the high cost of a single dose, there was a reduction in the cost while using Imipenem due to the decrease of the time of treatment of patients in the hospital and the intensive care unit and no expenses for additional antibacterial drugs. Imipenem can be used as monotherapy as an alternative to the standard combination therapy in severe nosocomial pneumonia, primarily in patients located in intensive care unit.

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T.A.Luchnikova, O.B.Prikhodko. Features of clinical course of asthma in pregnant women depending on the level of exhaled nitrogen oxide and vitamin D in the Organism 

The aim of the study was to investigate the contents of exhaled nitrogen oxide and vitamin D level in the blood serum of patients with asthma in the dynamics of pregnancy and establish the extent of influence of their concentration on the clinical course of the disease and the state of health of posterity. 96 pregnant women with asthma were examined; among them there were 33 patients with controlled asthma, 39 with partially controlled one, and 24 with uncontrolled asthma. 47 patients had mild asthma, 43 patients had moderate asthma and 6 had severe asthma. The comparison group consisted of 26 pregnant women without bronchopulmonary pathology. Clinical and anamnestic data, results of lung function study were used; the level of exhaled nitrogen oxide and concentration of vitamin D in blood serum were determined in dynamics of pregnancy in patients depending on severity of the disease and level of monitoring. The state of health of newborns from pregnant women with asthma was assessed. It was found out that patients with severe asthma in comparison with mild and moderate ones had higher level of NOex during pregnancy: from 46.3±5.0 ppb in the 1st trimester till 59.0±3.2 ppb in the 3rd trimester (р<0.05). Average level of vitamin D in pregnant women with asthma was 23.26±1.5 ng/ml; in the control group it was 36.1±0.74, which indicates insufficient levels of vitamin D in patients with asthma during pregnancy. In pregnant patients with asthma NOex level and vitamin D contents correlated with the severity of the disease, the level of control of asthma and duration of gestation. At the stage of screening all pregnant women with vitamin D deficiency were registered to have intrauterine growth retardation, and while assessing the condition of the newborn by Apgar low rates were found in children from mothers with low vitamin D. The levels of NOex and vitamin D in pregnant woman can be used to determine the dynamics of the disease in the gestation period.

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M.T.Lutsenko. Motion activity of airway ciliated epithelium in patients with asthma

At asthma in bronchial mucous tunic as a result of chronic inflammatory process the working of mucociliary system is disturbed and there is restructuring of epithelial layer. The number of ciliary cells at the severe form of asthma decreases till 70%. The reason of restructuring of ciliated epithelium is the accumulation of a big number of fatty acids peroxides in the mucous tunic. Under their influence there is a decrease of activity of succinate dehydrogenase and ATP in the basal bodies of ciliary cells. Under the severe form of asthma there is a suppression of activity of mucociliary clearance as a result of destruction of a big number of bronchial mucosa ciliated cells.

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S.S.Tseluyko, M.M.Gorbunov, S.V.Zinoviev, D.A.Reshodko. Scanning cryo-electron microscopy of rat lung at cold exposure

The aim of research is to investigate important structures in vivo of mucociliary conveyor of respiratory and airway parts of the lung of intact rats against general cooling by the method of scanning cryoelectron microscopy without fixation and dehydration. The rats (male) in an amount of 40 pieces were exposed to general cooling during 14 days for 3 hours per day at the temperature of -15ºC. Frozen in liquid nitrogen tracheal samples were placed on a freezing Pelzer table (-30ºC) of the consoles Deben Coolstage of scanning electron microscope Hitachi S-3400. The study was conducted at low vacuum (80Pa) using backscattered electrons detector (BSECOMP). It was found out that the epithelial lining of the trachea of rats is covered with a liquid layer consisting of viscous gel and aqueous phases masking ciliary epithelial cells. Mucous secretion of the bronchi is presented by single plates with mucus cellular elements. On the alveolar surface in the monolayer of surfactant there were discovered globular clusters of lattice surfactant. With total cooling on the surface of epithelial layer the amount of bronchial secretions increases, the structure of the mucociliary apparatus changes and tracheal mucosa surface becomes wavy and there are sometimes marked accumulations of mucus. In the epithelial lining there are identified areas with the predominance of ciliated epithelium goblet cells lacking microvilli. The secretory activity of goblet cells and type 2 alveolocytes of respiratory department is accompanied by an increased release of secretion causing a disturbance of mucociliary transport.

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N.V.Makarova. Comparative characteristics of renal blood flow in patients with chronic renal failure developed as a result of myeloma nephropathy and in primary nephrology pathology

A comparative analysis of the indicators of renal hemodynamics in patients with chronic renal failure/chronic kidney disease (CRF/CKD) developed against myeloma nephropathy (group 1) and with primary kidney disease (group 2) was done. 20 patients were included in the first group, 14 patients were in the second one, and in most cases there was Stage 3 CRF/CKD. There were analyzed the following indicators of renal blood flow: peak systolic velocity, end diastolic velocity, mean flow velocity throughout the entire cardiac cycle, resistive index and pulsation index. Circulation figures were recorded at the level of basic, segmental, interlobar, arc, interlobular renal arteries. It is concluded that violations of renal blood flow and vascular resistance in patients with multiple myeloma complicated by chronic renal failure are primarily due to CKD itself. The differences in the two groups of patients with CRF/CKD were only about the average level in the parenchymal blood flow velocity (interlobular, arcuate, interlobar arteries); at myeloma nephropathy it was significantly reduced in comparison with the control group and patients with CRF/CKD without hemoblastosis. The rest velocity parameters were significantly reduced and vascular resistance indices were increased in comparison with the control and did not differ in groups of patients with CRF/CKD. Thus, hemodynamic changes at the level of parenchyma are the most important for patients with multiple myeloma, which suggests more severe violations of kidneys in these patients with the complication of CRF.

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I.N.Gorikov, М.Т.Lutsenko, I.A.Andrievskaya. The method of early diagnostics of the threat of miscarriage under primary placental insufficiency in women with influenza A(H3N2) in the first trimester of pregnancy

To develop the method of early diagnostics of the threat of miscarriage under primary placental insufficiency in 102 women at influenza virus A(HN2) there was studied the vessel resistance in the right and left uterine arteries, ultrastructure of uterine and villous chorion; in the blood serum there were defined titers of antivirus antibodies, concentration of mean molecular peptides, seromucoid and circulating immune complexes (the main group). 30 women with physiologic course of pregnancy were included in the control group. Among the patients of the main group there were three subgroups. The first group had 36 patients with influenza virus A(H3N2) (antibody titers were 1:4-1:16), the second group had 34 pregnant women with influenza infection (antibody titers were 1:8-1:32), and the third group included 32 women with influenza virus А(Н3N2) (antibody titers were 1:32-1:128), in whom clinical and echographic signs of the threat of miscarriage developed at the 6-8th day of the disease. It was found out that in the patients of the third group at the 2-4th day of the virus infection in the blood serum there was the increase of the contents of mean molecular peptides till 0.290±0.0011 units of optical density, of seromucoid till 0.119±0.0011 units of optical density and of circulating immune complexes till 0.221±0.0021 units of optical density (in the second subgroup it was 0.259±0.0013 units of optical density, р<0.001; 0.115±0.0013 units of optical density, р<0.001; 0.190±0.0020 units of optical density, р<0.001, respectively). This caused the increase of the value of systolic-diastolic ratio in the right uterine artery till 3.18±0.009 standard units, and in the left till 3.20±0.015 standard units (in the second group it was 2.97±0.014 standard units, р<0.001 and 2.96±0.013 standard units, р<0.001, respectively) and it led to the development of clinical-ultrasound signs of the threat of miscarriage at the 6-8th day of the infectious disease in 100 % of women.

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L.G.Nakhamchen, I.N.Gorikov, V.P.Kolosov, A.N.Odireev, V.I.Reznik, T.V.Smirnova, A.V.Kolosov, E.I.Karapetyan. The changes in cytokins level at the exacerbation of chronic simple bronchitis caused by virus of parainfluenza of the third type in women in the first trimester of pregnancy

The contents of interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in the blood serum were studied in 89 women in the first trimester of pregnancy. The first group (control) was made out of 25 women with uncomplicated pregnancy; the second had 23 women with the exacerbation of chronic simple bronchitis caused by parainfluenza of the 3rd type with antibody titer 1:16-1:64; the third one consisted of 21 patients with the exacerbation of chronic simple bronchitis induced by parainfluenza infection with antibody titers 1:32-1:128; the fourth group had 20 women with exacerbation of chronic simple bronchitis of parainfluenza etiology with antibody titer 1:64-1:256 at early stages of gestation. In the second group in comparison with the first one there were higher contents of IL-4: 21.1±2.00 pg/ml and INF-γ: 29.5±2.31 pg/ml than in the control group: 12.9±1.16 pg/ml (р<0.001) and 22.3±2.08 pg/ml (р<0.05), respectively. In the third group in comparison with the first one there were higher values of IL-4 (the growth by 132.6%, р<0.001), TNF-α (by 36%, p<0.01) and IFN-γ (by 43%, p<0.01). The patients in the fourth group in comparison with the third one did not have significant differences in TNF-α and IFN-γ. Buy there was the decrease of the level of IL-4 by 11.3% (р<0.05) that shows the imbalance of cytokines in women with exacerbation of chronic simple bronchitis caused by parainfluenza of the third type with antibody titer 1:64-1:256 at early stages of gestation. This may lead to persistent course of infectious-inflammatory process as well as to autoimmune damage of vital organs and the formation of initial placental insufficiency.

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I.N.Gorikov, М.Т.Lutsenko. Ultrasound characteristic of thymus gland in mature newborns from mothers with influenza A(H3N2) in the first trimester of pregnancy

Ultrasound characteristic of thymus gland was studied in 109 mature newborns at the 3-5th days of life. All the examined patients were divided into 4 groups. The first group (control) included 30 healthy newborns of 38-40 weeks from mothers with physiologic course of pregnancy. The second group had 28 newborns whose mothers at early stages of gestation suffered influenza virus А(Н3N2) with antibody titer 1:4-1:16; in the third group there were 26 children of 38-40 weeks from mothers who suffered in the first trimester of pregnancy influenza virus A(H3N2) with antibody titer 1:8-1:32; the fourth group consisted of 25 newborns from mothers who suffered at early stages of gestation influenza virus A(H3N2) with antibody titer 1:32-1:128. The children in the second and the third group in comparison with the first one did not have any changes of organometric parameters of the immune organ. In the newborns of the fourth group the length of the thymus gland decreased till 3.8±0.11 cm, the width till 2.4±0.06 cm, the mass till 8.6±0.53 g and the volume of the organ till 6.0±0.37 sm3. In the first group these parameters were 4.2±0.09 cm (р<0.05), 2.8±0.05 cm (р<0.001), 10.5±0.37 g (р<0.01), 7.4±0.25 sm3 (р<0.01), respectively. This suggests the suppression of organogenesis of thymus in children with antenatal anamnesis burdened with influenza virus А(Н3N2) with antibody titer 1:32-1:128 in their mothers at early stages of gestation

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N.A.Ishutina, I.N.Gorikov, I.А.Аndrievskaya. The state of hepatobiliary system in term newborns from mothers who suffered influenza virus A(H3N2) in the first trimester of pregnancy

The functional state of liver in 112 term newborns, who depending on their antenatal ontogenesis were divided into 4 groups, was studied. The first group (control) was made of 30 healthy newborns from mothers with physiological course of pregnancy; the second group consisted of 30 children whose mothers suffered influenza A(H3N2) (antibody titers were 1:4-1:16), the third group had 27 newborns with antenatal anamnesis complicated with influenza A(H3N2) (antibody titers were 1:8-1:32) and the fourth group had 25 children whose mothers suffered A(H3N2) (antibody titers were 1:32-1:128) at early stages of gestation. In newborns in the serum of the umbilical blood there were found the contents of total protein, albumins, total, indirect and direct bilirubin, activity of alanine aminotransferase, serum glutamate-oxaloacetate-transaminase, gamma-glutamyl transpeptidase, lactic dehydrogenase and alkaline phosphatase, concentration of total cholesterol, lipoproteins of low density and triglycerides. In babies from mothers who suffered influenza infection with antibody titers 1:32-1:128 there was the decrease of total protein till 55.1±1.27 g/l (in the control group it was 62.1±1.45 g/l; р<0.01) and albumins till 34.2±1.01 g/l (in the control it was 38.2±1.13 g/l; р<0.05) against the increase of total bilirubin till 35.5±1.29 mcmole/l (in the control it was 25.3±1.67 g/l; р<0.001), of indirect bilirubin till 33.2±1.28 mcmole/l (in the control it was 23.4±1.67 mcmole/l; р<0.001), of direct bilirubin till 2.33±0.10 mcmole/l (in the control it was 1.91±0.09; р<0.01) and the activity of alkaline phosphatase till 175.7±10.62 МЕ/l (in the control it was 141.6±6.39 МЕ/l; р<0.01). This showed the suppression of protein-synthesizing and pigment function of the liver as well as of the process of cholestasis. At the same time there was the decrease of total cholesterol till 1.83±0.06 mmole/l (in the control it was 2.08±0.07 mmole/l; р<0.01) and lipoproteins of high density till 1.02±0.06 mmole/l (in the control it was 1.27±0.06 mmole/l; р<0.01). Their concentration causes the stability of cellular membranes and hypothalamic-pituitarium-adrenal system in newborns to unfavourable factors in the early postnatal period of their development.

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N.V.Simonova, V.A.Dorovskikh, R.A.Anokhina, E.Yu.Yurtaeva, M.A.Shtarberg. Lipid peroxidation of the liver in the conditions of heat exposure and introduction of phytoadaptogens

Modern environmental conditions dramatically increased the level of radical forming processes in the body. Heat exposure stimulates the generation of reactive oxygen species inducing peroxidation of lipids as a result of the development of hypoxia. In experimental conditions the possibility to correct free radical lipid oxidation of rats’ organism membranes was studied with the oral introduction of the phytoadaptogens that contain the complex of natural antioxidants. The animals were divided into 5 groups and each of them had 30 rats: intact animals (1) which were held in standard conditions of vivarium; the control group (2) in which rats were exposed to heat during forty-five minutes daily; the experimental groups (3, 4, 5) in which before the effects of heat animals had a daily oral intake of the extracts of Eleutherococcus, Rhodiola, liquorice in a dose of 1 ml/kg. It was found out that in the liver tissue of experimental animals a daily heat exposure during forty-five minutes contributes to the increase of lipid hydroperoxides level (by 34-41%), of diene conjugate (by 45-50%), and of malonic dialdehyde (by 62-74%) against the decrease of antioxidant system activity in the liver of intact animals. The introduction of phytoadaptogens to rats in the conditions of heat exposure contributes to the reliable decrease in the liver of lipid hydroperoxides by 22-28%, of diene conjugates by 22-32%, and of malonic dialdehyde by 30-37% in comparison with the rats of the control group. While analyzing the effect of the phytoadaptogens on the activity of the components of antioxidant system it was shown that the level of ceruloplasmin in the liver of animals was reliably higher by 68-82%, of vitamin E by 42-65% in comparison with the same parameters of the rats of the control group. So, the application of phytoadaptogens in the conditions of long heat exposure of the organism of animals under experiment leads to the stabilization of the processes of peroxidation against the increase of antioxidant system activity.

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E.A.Litovchenko, N.V.Korshunova. The protective influence of a mixture of adaptogenic products from hypericum perforatum and rhodiola rosea on warm-blooded organism under cold and heat stress

In the experimental conditions the possibility of increasing the resistance of rats to physical influence in the conditions of the use of a mixture of adaptogenic products (Hypericum perforatum and Rhodiola rosea) under cold and heat stress was studied. The animals were divided into 9 groups, each of them had 10 rats: the 1st group had intact animals which were held in standard conditions of vivarium; the 2nd group was the control group in which rats were exposed to cold during three hours daily (-15ºC, 50% humidity); the 3rd was the control group in which rats were exposed to heat during 45 minutes daily (+40ºC, 50% humidity); the 4th, 6th, 8th groups were the experimental groups in which before cooling animals had a daily intake of powder mixture of Hypericum perforatum and Rhodiola rosea in a dose of 30 mg/kg, 150 mg/kg, 300 mg/kg, respectively; the 5th, 7th, 9th groups were the experimental groups in which rats before being put in the heat climatic chamber were given a daily intake of powder mixture of Hypericum perforatum and Rhodiola rosea in a dose of 30 mg/kg, 150 mg/kg, 300 mg/kg, respectively. It was found out that cold and heat exposure reduces the resistance of experimental animals (in different degrees) to swimming in all the days of the experiment. Thus the length of swimming of intact animals was 146±3.4 min; whereas in animals under cold exposure in the control group it was 108±5.6 min, and under the exposure to heat it was 105±3.4 min (p<0.01). The introduction of a mixture of Hypericum perforatum and Rhodiola rosea into the food of animals, exposed to temperature effects in a dose of 150-300 mg/kg increased swimming time under exposure to cold up to 178±4.7 min (р<0.05) and under exposure to heat up to 181±3.0 min (р<0.05). At the 14th day the average duration of swimming of rats which took the mixture at a dose of 150-300 mg/kg against exposure to cold and heat was 192±3.0 min and 188±5.9 min, respectively. A similar trend was observed till the 28th day of research. Thus, the use of a mixture of Hypericum perforatum and Rhodiola rosea in conditions of prolonged heat and cold stress on the organism of experimental animals leads to significant increase in the resistance of rats to fatigue.

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А.V.Leyfa, О.V.Yurechko, L.V.Voytus. The features of muscular and psycho-emotional state of tennis players depending on the level of their sports efficiency

The article deals with the features of psycho-emotional state of women tennis players of different sports qualification. The results of the study showed that sportswomen who have low sports efficiency are more communicative and they are more emotional and subject to other people’s influence. As a rule they have inflated self-esteem, limit-exceeding conservatism and a low level of imagination. Tennis players of this group have superfluous courage, they are very expressive and anxiety and tension in this qualification group exceed the norms.

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SELECTED REPORTS
V.V.Voytsekhovskiy, Yu.S.Landyshev, N.D.Goborov, E.A.Filatova. Pulmonary embolism in the onset of genetic hematogenical thrombophilia

Hematogenous thrombophilia is often encountered in the clinical practice of doctors of all specialties. The article presents current data on the diagnostic of this pathology. In most cases pulmonary embolism is a clinical onset of hereditary hematogenous thrombophilia. According to the authors of this article, pulmonary embolism occurred in 60% of surveyed patients with hereditary thrombophilia hematogenous. Current antithrombotic therapy is quite effective in this category of patients. Three cases of personal experience of the authors when there was diagnosed a combined form of hematogenous thrombophilia with serious thrombotic complications in anamnesis are shown. Adequate secondary prevention of thrombosis contributed to further disease-free course of the disease.

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REVIEWS
P.F.Kiku, D.S.Gigaev, N.S.Shiter, K.M. Sabirova, M.A.Mezentseva. The concept of risk factors for the health of the population

А systematic view on the concept of risk types of human health is presented; the main directions of the analysis of the influence of social factors on individual and population health are described. A number of approaches to the classification of risk factors take into account the form of exposure, the risk from exposure to environmental factors and social risk factors and their influence on an individual. There are five areas of analysis of the influence of social factors on individual and population health: essential-oriented; structured; detail-oriented; empirically-oriented; specially-oriented. Groups of risk factors affecting health equally relevant to men and women were distinguished: the first group was made based on socio-economic factors (low level of education; uncomfortable household; poor nutrition depending on material welfare and social status of the population (67% of the population); the second group of factors was formed according to the lifestyle (smoking, alcohol consumption, low physical activity, lack of prevention of the basic diseases (91% of the population); the third group included medical-biological factors (people older than 50, chronic diseases being a background of deteriorating health and the reason for new diseases development (52% of the population). The methods of management of social risks to human health which are the methods of influence on the person as an individual and on society and public consciousness in general are presented. Identification of risk factors for human health determines the direction of operation of health institutions in taking treatment, rehabilitation, preventive and anti-epidemic measures.

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K.Yu.Stokoz, D.S.Lysyak. History of study of pre-eclampsia and eclampsia in obstetrics

Pre-eclampsia/eclampsia is one of the most serious pregnancy complications in modern obstetrics. The article presents the historical data about the study of pre-eclampsia and eclampsia since the 4th century BC. The evolution of terminology is presented. According to the development of medical science there appeared a new theory of the etiology and the conception of pathogenesis developed. It shows the contribution of Russian scientists to improve methods of diagnosis, treatment and prevention of this complication of pregnancy. The achievements of modern obstetric science allow to predict pre-eclampsia from early pregnancy. Despite long history of studying, many aspects of this problem still remain unresolved.

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